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Results for "

Plasminogen Activator

" in MedChemExpress (MCE) Product Catalog:

By Targets:	PAI-1 (26) AMPK (2) Amyloid-β (1) Androgen Receptor (1) Antibiotic (1) Apoptosis (10) Biochemical Assay Reagents (1) ERK (1) IGF-1R (2) JNK (1) Mitophagy (2) MMP (4) Potassium Channel (1) Progesterone Receptor (1) Reactive Oxygen Species (1) Ser/Thr Protease (10) Sodium Channel (5) TRP Channel (5)
By Research Areas:	Cancer (18) Cardiovascular Disease (20) Endocrinology (1) Infection (1) Inflammation/Immunology (9) Metabolic Disease (8) Neurological Disease (6)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: PAI-1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108865

Alteplase Actilyse; Activase	Others	Cardiovascular Disease
Alteplase (Actilyse; Activase), a tissue plasminogen activator prepared by recombination, is a thrombolytic agent that play important roles in acute ischemic stroke, pulmonary embolism, acute myocardial infarction, and occluded catheters .

HY-122098

Diaplasinin PAI-749	PAI-1	Cardiovascular Disease
Diaplasinin (PAI-749) is a plasminogen activator inhibitor-1 (PAI-1) inhibitor with IC₅₀ of 295 nM. Diaplasinin has antithrombotic efficacy .

HY-108904

Urokinase, Human urine Urokinase-type Plasminogen Activator; Uronase; Win 22005; Win-Kinase	Ser/Thr Protease	Cardiovascular Disease Cancer
Urokinase (peptidolytic) (EC 3.4.21.73) is a serine protease, an inactive form (zymogen) of the serine protease plasminogen. Activation of plasmin triggers a proteolytic cascade reaction, which in turn participates in thrombolysis or extracellular matrix degradation, implicated in vascular disease and cancer-related research .

HY-106508

Fendosal HP 129; P 71-0129	PAI-1	Inflammation/Immunology
Fendosal (HP 129) is an orally active, potent non-steroidal anti-inflammatory agent. Fendosal (HP 129) is also an inhibitor of Plasminogen activator inhibitor-1 (PAI-1) .

HY-N10227

Geodin	PAI-1 Antibiotic	Infection Inflammation/Immunology
Geodin, a fungal metabolite, shows antibacterial activity. Geodin also is an inhibitor of plasminogen activator inhibitor- 1 (PAI-1) .

HY-P2824

Streptokinase, β-hemolytic streptococcus (Lancefield Group C)	Others	Cardiovascular Disease
Streptokinase, β-hemolytic streptococcus (Lancefield Group C) is a bacteria-derived protein and a plasminogen activator. Streptokinase is widely used for the research of the blood-clotting disorders. Streptokinase improves reperfusion blood flow after coronary artery occlusion .

HY-P2230

Angstrom6 A6 Peptide	PAI-1	Cancer
Angstrom6 (A6 Peptide) is an 8 amino-acid peptide derived from single-chain urokinase plasminogen activator (scuPA) and interferes with the uPA/uPAR cascade and abrogates downstream effects. Angstrom6 binds to CD44 resulting in the inhibition of migration, invasion, and metastasis of tumor cells, and the modulation of CD44-mediated cell signaling .

HY-117724

AZ3976	PAI-1	Cardiovascular Disease
AZ3976 is a potent plasminogen activator inhibitor type 1 (PAI-1) inhibitor with an IC₅₀ value of 26 μM in an enzymatic chromogenic assay. AZ3976 is active with an IC₅₀ of 16 μM in a plasma clot lysis assay. AZ3976 does not bind to active PAI-1 but bound reversibly to latent PAI-1. AZ3976 inhibits PAI-1 by enhancing the latency transition of active PAI-1. AZ3976 displays profibrinolytic activities in a human plasma clot lysis assay .

HY-122311

Orniplabin SMTP-7	Reactive Oxygen Species	Neurological Disease Inflammation/Immunology
Orniplabin (SMTP-7) is a low-molecular-weight compound that enhances plasminogen–fibrin binding, urokinase-catalyzed activation of plasminogen, and urokinase and plasminogen-mediated fibrin degradation. Orniplabin shows potential thrombolytic and anti-inflammatory effects. Orniplabin inhibits ROS .

HY-101214

UK-371804

PAI-1 Inflammation/Immunology

UK-371804 is a urokinase-type plasminogen activator (uPA) inhibitor with a K_i of 10 nM.
HY-P4338

Glutaryl-Gly-Arg-AMC

PAI-1 Others

Glutaryl-Gly-Arg-AMC is a peptide substrate of urokinase plasminogen activator (uPA) .
HY-100447

TM5275 sodium

4 Publications Verification

PAI-1 Cardiovascular Disease Cancer

TM5275 sodium is a plasminogen activator inhibitor (PAI-1) with an IC₅₀ of 6.95 μM.

UK-371804	PAI-1	Inflammation/Immunology
UK-371804 is a urokinase-type plasminogen activator (uPA) inhibitor with a K_i of 10 nM.

Glutaryl-Gly-Arg-AMC	PAI-1	Others
Glutaryl-Gly-Arg-AMC is a peptide substrate of urokinase plasminogen activator (uPA) .

TM5275 sodium 4 Publications Verification	PAI-1	Cardiovascular Disease Cancer
TM5275 sodium is a plasminogen activator inhibitor (PAI-1) with an IC₅₀ of 6.95 μM.

HY-122542

PPACK	PAI-1	Cardiovascular Disease
PPACK is a plasminogen activator (rt-PA) inhibitor. PPACK can inhibit changes in fibrin degradation products, plasminogen and alpha 2-antiplasmin. PPACK also inhibits the binding of rt-PA to plasma protease inhibitors .

HY-P5981

Chromozym t-PA

Biochemical Assay Reagents Others

Chromozym t-PA can be used for determination of t-PA (tissue plasminogen activator) concentration
HY-101214A

UK-371804 hydrochloride

UK-371804 hydrochloride (compound 24) is a urokinase-type plasminogen activator (uPA) inhibitor with a K_i of 10 nM .

Chromozym t-PA	Biochemical Assay Reagents	Others
Chromozym t-PA can be used for determination of t-PA (tissue plasminogen activator) concentration

UK-371804 hydrochloride
UK-371804 hydrochloride (compound 24) is a *urokinase-type plasminogen* activator (uPA) inhibitor with a K_i** of 10 nM .

HY-122542B

PPACK TFA	PAI-1	Cardiovascular Disease
PPACK TFA is a plasminogen activator (rt-PA) inhibitor. PPACK TFA can inhibit changes in fibrin degradation products, plasminogen and alpha 2-antiplasmin. PPACK TFA also inhibits the binding of rt-PA to plasma protease inhibitors .

HY-E70230

Staphylokinase, staphylococcus aureus SAK	Others	Cardiovascular Disease
Staphylokinase, staphylococcus aureus (SAK) is a fibrin-specific plasminogen activator. Staphylokinase is an efficient, fibrin-selective thrombolytic agent .

HY-N1533

28-O-β-D-Glucopyranosyl pomolic acid

28-O-β-D-Glucopyranosyl pomolic acid is a urokinase plasminogen activator inhibitor with IC₅₀ at 37.82 μM .

28-O-β-D-Glucopyranosyl pomolic acid
28-O-β-D-Glucopyranosyl pomolic acid is a urokinase plasminogen activator inhibitor with IC₅₀ at 37.82 μM .

HY-B0111

Drospirenone Dihydrospirorenone	Progesterone Receptor Androgen Receptor	Endocrinology Cancer
Drospirenone (Dihydrospirorenone) is an orally active fourth-generation progestin that interacts with the progesterone receptor (PR) and androgen receptor (AR). Drospirenone significantly decreases both plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (tPA) via the AR. Drospirenone can produce DNA damage in bone marrow cells of female mice. .

HY-15253

Tiplaxtinin 5+ Cited Publications PAI-039; Tiplasinin	PAI-1 Apoptosis	Metabolic Disease Cancer
Tiplaxtinin is a selective and orally efficacious inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC₅₀ of 2.7 μM .

HY-108845

Tenecteplase TNK-tPA	Others	Metabolic Disease
Tenecteplase (TNK-tPA) is a modified tissue plasminogen activator. Tenecteplase (TNK-tPA) can be used for acute ischaemic stroke diseases research .

HY-137495

GGACK

PAI-1 Ser/Thr Protease Cancer

GGACK (H-Glu-Gly-Arg-CMK) is an irreversible substrate-like serine protease urokinase-type plasminogen activator (uPA) inhibitor .

GGACK	PAI-1 Ser/Thr Protease	Cancer
GGACK (H-Glu-Gly-Arg-CMK) is an irreversible substrate-like *serine protease urokinase-type plasminogen* activator (uPA)** inhibitor .

HY-B0099

Edaravone 15+ Cited Publications MCI-186	MMP Apoptosis	Neurological Disease
Edaravone is a strong novel free radical scavenger, and inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator.

HY-16511

Upamostat 1 Publications Verification WX-671	Ser/Thr Protease PAI-1	Cancer
Upamostat (WX-671) is a serine protease inhibitor. Upamostat is the orally available prodrug of the WX-UK1, which is a urokinase plasminogen activator (uPA) inhibitor.

HY-B0099S

Edaravone-d5 MCI-186-d₅	MMP Apoptosis	Neurological Disease
Edaravone-d₅ is a deuterium labeled Edaravone. Edaravone is a strong novel free radical scavenger, and inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator[1][2][3][4].

HY-N0518

Toddalolactone 1 Publications Verification	PAI-1	Cardiovascular Disease
Toddalolactone, a main component of Toddalia asiatica, inhibits the activity of recombinant *human plasminogen* activator inhibitor-1 (PAI-1)**, with an IC₅₀ value of 37.31 μM .

HY-135715

(E)-UK122 TFA

Others Others

(E)-UK122 TFA is the isomer of UK122 TFA. UK122 is a potent and selective urokinase-type plasminogen activator (uPA) inhibitor with an IC50 of 0.2 μM .

(E)-UK122 TFA	Others	Others
(E)-UK122 TFA is the isomer of UK122 TFA. UK122 is a potent and selective urokinase-type plasminogen activator (uPA) inhibitor with an IC50 of 0.2 μM .

HY-122714

SK-216	PAI-1	Cancer
SK-216 is a plasminogen activator inhibitor-1 (PAI-1) inhibitor that acts as an anti-metastatic agent for human osteosarcoma and inhibits lung metastasis of human osteosarcoma .

HY-114330A

ZK824859 hydrochloride	PAI-1 Ser/Thr Protease	Inflammation/Immunology
ZK824859 hydrochloride is an oral available and selective urokinase plasminogen activator (uPA) inhibitor with IC₅₀s of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively .

HY-126361

ZK824190	Ser/Thr Protease PAI-1	Inflammation/Immunology
ZK824190 is an orally available and selective urokinase plasminogen activator (uPA) inhibitor as a potential treatment for multiple sclerosis. IC₅₀s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively .

HY-114330

ZK824859	PAI-1 Ser/Thr Protease	Inflammation/Immunology
ZK824859 is an oral available and selective urokinase plasminogen activator (uPA) inhibitor with IC₅₀s of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively .

HY-126361A

ZK824190 hydrochloride	Ser/Thr Protease PAI-1	Inflammation/Immunology
ZK824190 hydrochloride is an orally available and selective urokinase plasminogen activator (uPA) inhibitor as a potential treatment for multiple sclerosis. IC₅₀s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively .

HY-B0285

Amiloride Maximum Cited Publications 25 Publications Verification MK-870	Sodium Channel TRP Channel Apoptosis	Cardiovascular Disease Metabolic Disease
Amiloride (MK-870) is an inhibitor of both epithelial sodium channel (ENaC ) and urokinase-type plasminogen activator receptor (uTPA ). Amiloride is a blocker of polycystin-2 (PC2; TRPP2 ) channel.

HY-B0285A

Amiloride hydrochloride Maximum Cited Publications 25 Publications Verification MK-870 hydrochloride	Sodium Channel TRP Channel Apoptosis	Cardiovascular Disease Metabolic Disease
Amiloride hydrochloride (MK-870 hydrochloride) is an inhibitor of both epithelial sodium channel (ENaC ) and urokinase-type plasminogen activator receptor (uTPA ). Amiloride hydrochloride is a blocker of polycystin-2 (PC2; TRPP2 ) channel.

HY-B0149

Tranexamic acid 1 Publications Verification cyclocapron	IGF-1R AMPK MMP Mitophagy	Cardiovascular Disease Neurological Disease Cancer
Tranexamic acid (cyclocapron), a cyclic analog of lysine, is an orally active antifibrinolytic agent. Tranexamic acid attenuates the effects of severe trauma, inhibits urokinase plasminogen activator and ameliorates dry wrinkles. Tranexamic acid can used for the research of hemostasis .

HY-B0285B

Amiloride hydrochloride dihydrate Maximum Cited Publications 25 Publications Verification MK-870 hydrochloride dihydrate	Sodium Channel Apoptosis TRP Channel	Cardiovascular Disease Metabolic Disease
Amiloride hydrochloride dihydrate (MK-870 hydrochloride dihydrate) is an inhibitor of both epithelial sodium channel (ENaC ) and urokinase-type plasminogen activator receptor (uTPA ). Amiloride hydrochloride dihydrate is a blocker of polycystin-2 (PC2; TRPP2 ) channel.

HY-N1504

Loureirin B	PAI-1 Potassium Channel ERK JNK	Metabolic Disease
Loureirin B, a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of plasminogen activator inhibitor-1 (PAI-1), with an IC₅₀ of 26.10 μM; Loureirin B also inhibits K_ATP, the phosphorylation of ERK and JNK, and has anti-diabetic activity.

HY-116868

Anecortave acetate Anecortave	PAI-1	Cardiovascular Disease
Anecortave acetate is a potent ocular angiostatic agent. Anecortave acetate inhibits neovascularization which is induced by many different angiogenic factors, and increases plasminogen activator inhibitor-1 (PAI-1) mRNA expression. Anecortave acetate can be used to research ocular neovascular diseases .

HY-119160

TM5007	PAI-1	Inflammation/Immunology Cancer
TM5007 is a poent and orally active inhibitor of plasminogen activator inhibitor-1 (PAI-1) with an IC₅₀ of 29 μM. TM5007 enhance fibrinolysis activity and inhibits coagulation. TM5007 also prevents the fibrotic process initiated by bleomycin in mouse lung .

HY-W018723

4-Aminobenzamidine dihydrochloride 1 Publications Verification p-Aminobenzamidine dihydrochloride	Ser/Thr Protease	Cancer
4-Aminobenzamidine (p-Aminobenzamidine) dihydrochloride is a strong trypsin inhibitor, also acting as a relatively weak urokinase type plasminogen activator (uPA) inhibitor (K_i=82 μM). 4-Aminobenzamidine can inhibit growth of a human prostate tumor in SCID mice .

HY-B0285AR

Amiloride hydrochloride (Standard) 5+ Cited Publications MK-870 hydrochloride (Standard)	Sodium Channel TRP Channel Apoptosis	Cardiovascular Disease Metabolic Disease
Amiloride (hydrochloride) (Standard) is the analytical standard of Amiloride (hydrochloride). This product is intended for research and analytical applications. Amiloride hydrochloride (MK-870 hydrochloride) is an inhibitor of both epithelial sodium channel (ENaC ) and urokinase-type plasminogen activator receptor (uTPA ). Amiloride hydrochloride is a blocker of polycystin-2 (PC2; TRPP2 ) channel.

HY-14759

Aleplasinin PAZ-417	PAI-1 Amyloid-β	Neurological Disease
Aleplasinin is an orally active, potent, BBB-penetrated and selectiveSERPINE1 (PAI-1, Plasminogen activator inhibitor-1) inhibitor. Aleplasinin increases amyloid-β (Aβ) catabolism and ameliorates amyloid-related pathology. Aleplasinin improves memory deficiency. Aleplasinin can be used for Alzheimer's disease research .

HY-100415

UKI-1 WX-UK1; UKI-1C	PAI-1 Ser/Thr Protease	Cancer
UKI-1 (WX-UK1) is a potent *urokinase-type plasminogen* activator (uPA) inhibitor with a K_i of 0.41 μM. UKI-1 is also a low molecular weight serine protease** inhibitor. UKI-1 is a potent antimetastatic agent and inhibits the invasive capacity of carcinoma cells .

HY-B0149R

Tranexamic acid (Standard) cyclocapron (Standard)	IGF-1R AMPK MMP Mitophagy	Cardiovascular Disease Neurological Disease Cancer
Tranexamic acid (Standard) is the analytical standard of Tranexamic acid. This product is intended for research and analytical applications. Tranexamic acid (cyclocapron), a cyclic analog of lysine, is an orally active antifibrinolytic agent. Tranexamic acid attenuates the effects of severe trauma, inhibits urokinase plasminogen activator and ameliorates dry wrinkles. Tranexamic acid can used for the research of hemostasis .

HY-B0285AS

Amiloride-15N3 hydrochloride MK-870-¹⁵N₃ hydrochloride	Apoptosis TRP Channel Sodium Channel
Amiloride- ¹⁵N₃ (hydrochloride) is the ¹⁵N labeled Amiloride hydrochloride[1]. Amiloride hydrochloride (MK-870 hydrochloride) is an inhibitor of both epithelial sodium channel (ENaC[2]) and urokinase-type plasminogen activator receptor (uTPA[3]). Amiloride hydrochloride is a blocker of polycystin-2 (PC2;TRPP2[4]) channel.

HY-101761

TM5441 5+ Cited Publications	PAI-1 Apoptosis	Cancer
TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor-1 (PAI-1), has IC₅₀ values between 13.9 and 51.1 μM and induces intrinsic apoptosis in several human cancer cell lines. TM5441 attenuates Nω-nitro-l-arginine methyl ester-induced cardiac hypertension and vascular senescence .

HY-111056

UK122	Ser/Thr Protease	Cancer
UK122 is a potent and selective *urokinase-type plasminogen* activator (uPA) inhibitor with an IC₅₀** of 0.2 μM. UK122 shows no or little inhibition of tissue-type PA (tPA), plasmin, thrombin, and trypsin (all IC₅₀>100 μM). UK122, 4-oxazolidinone analogue, is an anticancer agent and inhibits cancer cell migration and invasion .

HY-101761A

TM5441 sodium	PAI-1 Apoptosis
TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor-1 (PAI-1), has IC₅₀ values between 13.9 and 51.1 μM. TM5441 induces intrinsic apoptosis in several human cancer cell lines. TM5441 attenuates Nω-nitro-l-arginine methyl ester-induced cardiac hypertension and vascular senescence .

Cat. No.	Product Name	Target	Research Area

HY-P2230

Angstrom6 A6 Peptide	PAI-1	Cancer
Angstrom6 (A6 Peptide) is an 8 amino-acid peptide derived from single-chain urokinase plasminogen activator (scuPA) and interferes with the uPA/uPAR cascade and abrogates downstream effects. Angstrom6 binds to CD44 resulting in the inhibition of migration, invasion, and metastasis of tumor cells, and the modulation of CD44-mediated cell signaling .

HY-114150

D-Val-Leu-Arg-pNA	Peptides	Others
D-Val-Leu-Arg-pNA is a glandular kininoreleasing enzyme substrate that also acts as a substrate for tissue-type plasminogen activator (t-PA) with no apparent affinity for fibrin .

HY-P10059

Boc-Val-Gly-Arg-βNA

Peptides Others

Boc-Val-Gly-Arg-βNA is a colorimetric substrate for plasminogen activator .
HY-P4338

Glutaryl-Gly-Arg-AMC

PAI-1 Others

Glutaryl-Gly-Arg-AMC is a peptide substrate of urokinase plasminogen activator (uPA) .

HY-122542

PPACK	PAI-1	Cardiovascular Disease
PPACK is a plasminogen activator (rt-PA) inhibitor. PPACK can inhibit changes in fibrin degradation products, plasminogen and alpha 2-antiplasmin. PPACK also inhibits the binding of rt-PA to plasma protease inhibitors .

HY-P5981

Chromozym t-PA

Biochemical Assay Reagents Others

Chromozym t-PA can be used for determination of t-PA (tissue plasminogen activator) concentration
HY-P1615

Cenupatide

Peptides Cancer

Cenupatide (UPARANT) is a Urokinase-type plasminogen activator receptor (uPAR) inhibitor. Cenupatide has anti-angiogenic and anti-inflammatory efficacy .
HY-P5355

Z-Gly-Gly-Arg-AFC

Peptides Others

Z-Gly-Gly-Arg-AFC is a biological active peptide. (Plasminogen Activator Acrosine Substrate, fluorescent Z-Gly-Gly-Arg-AFC)
HY-137495

GGACK

PAI-1 Ser/Thr Protease Cancer

GGACK (H-Glu-Gly-Arg-CMK) is an irreversible substrate-like serine protease urokinase-type plasminogen activator (uPA) inhibitor .

HY-P10005

D-Val-Gly-Arg-pNA	Peptides	Cardiovascular Disease
D-Val-Gly-Arg-pNA is a chromogenic substrate of TPA (tissue plasminogen activator). D-Val-Gly-Arg-pNA can be used to detect the amidolytic activity of TPA I and TPA II .

HY-P2333

LCKLSL	Peptides	Cardiovascular Disease
LCKLSL is a N-terminal hexapeptide and a competitive annexin A2 (AnxA2) inhibitor. LCKLSL potently inhibits the *binding of tissue plasminogen* activator (tPA) to AnxA2**. LCKLSL also inhibits the generation of plasmin and has anti-angiogenic roles .

HY-P2333A

LCKLSL hydrochloride 3 Publications Verification	Peptides	Cardiovascular Disease
LCKLSL hydrochloride is a N-terminal hexapeptide and a competitive annexin A2 (AnxA2) inhibitor. LCKLSL hydrochloride potently inhibits the *binding of tissue plasminogen* activator (tPA) to AnxA2**. LCKLSL hydrochloride also inhibits the generation of plasmin and has anti-angiogenic roles .

HY-P5018

NOTA-AE105	Peptides	Cancer
NOTA-AE105 is an PET ligand of *urokinase-type plasminogen* activator receptor (uPAR**), which can be radiolabeled by ⁶⁴Cu and ⁶⁸Ga. ⁶⁸Ga-NOTA-AE105 and ⁶⁴Cu-NOTA-AE105 shows high image contrast, resulting in clear tumor delineation .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0518

Toddalolactone 1 Publications Verification	Cardiovascular Disease Toddalia asiatica (L.) Lam. Classification of Application Fields Source classification Rutaceae Coumarins Phenylpropanoids Plants Disease Research Fields	PAI-1
Toddalolactone, a main component of Toddalia asiatica, inhibits the activity of recombinant *human plasminogen* activator inhibitor-1 (PAI-1)**, with an IC₅₀ value of 37.31 μM .

HY-N1504

Loureirin B	Dracaena cochinchinensis (Lour.) S. C. Chen Structural Classification Monophenols Flavonoids Classification of Application Fields Source classification Phenols Metabolic Disease Agavaceae Plants Dihydrochalcones Disease Research Fields	PAI-1 Potassium Channel ERK JNK
Loureirin B, a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of plasminogen activator inhibitor-1 (PAI-1), with an IC₅₀ of 26.10 μM; Loureirin B also inhibits K_ATP, the phosphorylation of ERK and JNK, and has anti-diabetic activity.

HY-N10227

Geodin	Human Gut Microbiota Metabolites Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Endogenous metabolite Disease Research Fields Inflammation/Immunology	PAI-1 Antibiotic
Geodin, a fungal metabolite, shows antibacterial activity. Geodin also is an inhibitor of plasminogen activator inhibitor- 1 (PAI-1) .

Species:	Human (11) Mouse (6) Rat (3)
Tag:	His (15) Tag Free (2) GST (1) Fc (3)
Source:	HEK293 (16) Sf9 insect cells (1) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P71077

	Serpin E1 Protein, Human (HEK293, His) Plasminogen Activator Inhibitor 1; PAI; PAI-1; Endothelial Plasminogen Activator Inhibitor; Serpin E1; SERPINE1; PAI1; PLANH1	Human	HEK293
	Serpin E1 is a serine protease inhibitor that regulates various cellular processes by inhibiting TMPRSS7, tissue-type plasminogen activator (PLAT), and urokinase-type plasminogen activator (PLAU). During fibrinolysis, it downregulates PLAT to control thrombus degradation and acts as a PLAU inhibitor to regulate cell adhesion. Serpin E1 Protein, Human (HEK293, His) is the recombinant human-derived Serpin E1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin E1 Protein, Human (HEK293, His) is 379 a.a., with molecular weight of ~44-51 kDa.

HY-P71133

	Serpin E1 Protein, Mouse (N172S, R253G, HEK293, His) Plasminogen Activator inhibitor 1; Endothelial Plasminogen Activator inhibitor; Serpin E1; Mr1; Pai1; Planh1;	Mouse	HEK293
	Serpin E1 Protein, a serine protease inhibitor, regulates TMPRSS7 and is a primary inhibitor for tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). It crucially down-regulates fibrinolysis, controlling blood clot degradation. As a PLAU inhibitor, Serpin E1 regulates cell adhesion and spreading, contributing to keratinocyte migration in cutaneous injury repair. Beyond protease inhibition, it regulates cell migration, influencing senescence, alveolar type 2 cells' senescence in the lung, cementogenic differentiation in periodontal ligament stem cells, and odontoblast differentiation in odontogenesis. Serpin E1 forms a heterodimer with TMPRSS7, interacts with proteins like VTN, PPP1CB, SORL1, LRP1, and PLAUR, emphasizing its multifaceted regulatory role. Serpin E1 Protein, Mouse (N172S, R253G, HEK293, His) is the recombinant mouse-derived Serpin E1 protein, expressed by HEK293 , with C-6*His labeled tag and N172S, R253G mutation. The total length of Serpin E1 Protein, Mouse (N172S, R253G, HEK293, His) is 380 a.a., with molecular weight of ~48.54 kDa.

HY-P73655

	Serpin E1 Protein, Rat (HEK293, His) Plasminogen Activator inhibitor 1; PAI-1; Serpin E1; Serpine1; Planh1	Rat	HEK293
	Serpin E1 Protein, Rat (HEK293, His) is one important member of the serine proteinase inhibitor E superfamily that plays a crucial role in the fibrinolytic system. The Serpin E1 protein is a single-chain glycoprotein composed of 379 amino acids. The active site of the protein is Arg346-Met347. SERPINE1 encodes plasminogen activator inhibitor type 1 (PAI-1), which serves as the primary inhibitor of urokinase plasminogen activator (uPA) and tissue-type plasminogen activator (tPA). The Serpin E1 protein can quickly inhibit the formation of plasmin. Serpin E1 can be transcribed through several signaling cascades, including pro-fibrogenic and pro-inflammatory pathways. Serpin E1 is a serine proteinase inhibitor, serves as an important regulator of extracellular matrix remodeling. Serpin E1 Protein, Rat (HEK293, His) is the recombinant rat-derived Serpin E1 protein, expressed by HEK293 , with C-His, C-10*His labeled tag. The total length of Serpin E1 Protein, Rat (HEK293, His) is 379 a.a., with molecular weight of 48-60 kDa.

HY-P73336

	Serpin E1 Protein, Rat (HEK293, Fc) Plasminogen Activator inhibitor 1; PAI-1; Serpin E1; Serpine1; Planh1	Rat	HEK293
	Serpin E1 is a serine protease inhibitor that regulates TMPRSS7 and inhibits tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). It can significantly downregulate fibrinolysis and control thrombus degradation. Serpin E1 Protein, Rat (HEK293, Fc) is the recombinant rat-derived Serpin E1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Serpin E1 Protein, Rat (HEK293, Fc) is 402 a.a., with molecular weight of ~70 kDa.

HY-P72055

	Serpin A5 Protein, Mouse (Baculovirus, His) Serpina5; Pci; Plasma serine protease inhibitor; Plasminogen Activator inhibitor 3; PAI-3; PAI3; Protein C inhibitor; PCI; Serpin A5	Mouse	Sf9 insect cells
	Serpin A5 protein is a heparin-dependent serine protease inhibitor that controls proteolytic activity in body fluids. It binds irreversibly to the serine activation site, inactivating serine proteases and regulating intravascular and extravascular proteolysis. Serpin A5 Protein, Mouse (Baculovirus, His) is the recombinant mouse-derived Serpin A5 protein, expressed by Sf9 insect cells , with N-10*His labeled tag. The total length of Serpin A5 Protein, Mouse (Baculovirus, His) is 381 a.a., with molecular weight of ~45.3 kDa.

HY-P70975

	Serpin A5 Protein, Human (HEK293, His) Plasma Serine Protease Inhibitor; Acrosomal Serine Protease Inhibitor; Plasminogen Activator Inhibitor 3; PAI-3; PAI3; Protein C Inhibitor; PCI; Serpin A5; SERPINA5; PCI; PLANH3; PROCI	Human	HEK293
	Plasma serine protease inhibitor (SERPINA5) is a glycoproteins that inhibit serine proteases. SERPINA5 is involved in the regulation of intravascular and extravascular proteolytic activities, controls the sperm motility and fertilization and protect components of the genital tract. SERPINA5 also inhibits urinary-type plasminogen activator-dependent tumor cell invasion and metastasis. Serpin A5 Protein, Human (HEK293, His) is the recombinant human-derived Serpin A5 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin A5 Protein, Human (HEK293, His) is 387 a.a., with molecular weight of 44-55 kDa.

HY-P73451

	T-PA Protein, Human (HEK293) T-PA; TPA; t-Plasminogen Activator; Tissue Plasminogen Activator	Human	HEK293
	The T-PA protein encoded by this gene is a secreted serine protease that converts plasminogen into plasmin, a key enzyme involved in tissue remodeling and cell migration. The proteolytic process produces heavy and light chains, forming heterodimeric enzymes. T-PA Protein, Human (HEK293) is the recombinant human-derived T-PA protein, expressed by HEK293 , with tag free. The total length of T-PA Protein, Human (HEK293) is 252 a.a., with molecular weight of ~35 kDa.

HY-P71051

	T-PA Protein, Human (HEK293, His) 1 Publications Verification T-PA; TPA; t-Plasminogen Activator; Tissue Plasminogen Activator;	Human	HEK293
	T-PA is a key proteolytic enzyme that coordinates the conversion of the abundant but inactive zymogen plasminogen to its active form plasmin via hydrolysis of a single Arg-Val bond. This enzymatic conversion helps regulate plasmin-mediated proteolysis, a key process in tissue remodeling, degradation, and various pathophysiological events. T-PA Protein, Human (HEK293, His) is the recombinant human-derived T-PA protein, expressed by HEK293 , with C-6*His labeled tag. The total length of T-PA Protein, Human (HEK293, His) is 527 a.a., with molecular weight of 60-75 kDa.

HY-P71050

	PLAU/uPA Protein, Human (411a.a, HEK293, His) Urokinase-Type Plasminogen Activator; U-Plasminogen Activator; uPA; PLAU	Human	HEK293
	uPA chain A Protein, a key player in the plasminogen activation system, selectively cleaves plasminogen, initiating fibrinolysis and contributing to tissue remodeling. Its precision underscores its role in regulating proteolytic activity, emphasizing its significance in the cascade of events leading to fibrinolysis and extracellular matrix remodeling in various physiological processes. PLAU/uPA Protein, Human (411a.a, HEK293, His) is the recombinant human-derived PLAU/uPA protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PLAU/uPA Protein, Human (411a.a, HEK293, His) is 411 a.a., with molecular weight of 45-55 kDa.

HY-P73561

	PLAU/uPA Protein, Rat (HEK293, His) Urokinase-type Plasminogen Activator; uPA; PLAU	Rat	HEK293
	PLAU/uPA proteins are characterized by a lack of conserved residues critical for feature annotation propagation, raising interesting questions about their structural and functional aspects. This uniqueness suggests potential differences in molecular interactions in plasminogen activation and fibrinolysis regulation. PLAU/uPA Protein, Rat (HEK293, His) is the recombinant rat-derived PLAU/uPA protein, expressed by HEK293 , with C-His labeled tag. The total length of PLAU/uPA Protein, Rat (HEK293, His) is 413 a.a., with molecular weight of 30-35 kDa.

HY-P73583

	T-PA Protein, Mouse (HEK293, Fc) Tissue-type Plasminogen Activator; t-PA; Plat	Mouse	HEK293
	The T-PA protein converts the inactive plasminogen to active plasmin by hydrolyzing a single Arg-Val bond. This conversion regulates plasmin-mediated proteolysis and is involved in tissue remodeling, degradation, and cell migration. T-PA also contributes to the prevention of polyspermy during oocyte activation by participating in the cortical granule reaction. T-PA Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived T-PA protein, expressed by HEK293 , with N-hFc labeled tag. The total length of T-PA Protein, Mouse (HEK293, Fc) is 251 a.a., with molecular weight of 55-60 kDa.

HY-P701312

	T-PA Protein, Mouse (HEK293, His) Tissue-type Plasminogen Activator; t-PA; Plat	Mouse	HEK293
	The T-PA protein converts the inactive plasminogen to active plasmin by hydrolyzing a single Arg-Val bond. This conversion regulates plasmin-mediated proteolysis and is involved in tissue remodeling, degradation, and cell migration. T-PA also contributes to the prevention of polyspermy during oocyte activation by participating in the cortical granule reaction. T-PA Protein, Mouse (HEK293, His) is the recombinant mouse-derived T-PA protein, expressed by HEK293 , with C-His labeled tag. The total length of T-PA Protein, Mouse (HEK293, His) is 527 a.a., with molecular weight of 13-15 kDa & 30-34 kDa & 35-40 kDa, respectively.

HY-P73467

	PLAU/uPA Protein, Human (431a.a, HEK293, His) Urokinase-type Plasminogen Activator; uPA; PLAU	Human	HEK293
	uPA chain A Protein, a key player in the plasminogen activation system, selectively cleaves plasminogen, initiating fibrinolysis and contributing to tissue remodeling. Its precision underscores its role in regulating proteolytic activity, emphasizing its significance in the cascade of events leading to fibrinolysis and extracellular matrix remodeling in various physiological processes. PLAU/uPA Protein, Human (431a.a, HEK293, His) is the recombinant human-derived PLAU/uPA protein, expressed by HEK293 , with C-His labeled tag. The total length of PLAU/uPA Protein, Human (431a.a, HEK293, His) is 431 a.a., with molecular weight of ~18 & 32 & 50 kDa, respectively.

HY-P702769

	uPAR Protein, Human (GST) Urokinase Plasminogen Activator surface receptor; U-PAR; CD87; PLAUR; MO3	Human	E. coli
	The uPAR protein is a receptor for urokinase plasminogen activator and actively localizes and promotes plasmin formation. It mediates proteolysis-independent signaling activated by U-PA and undergoes negative feedback regulation. uPAR Protein, Human (GST) is the recombinant human-derived uPAR protein, expressed by E. coli , with N-GST labeled tag.

HY-P72433

	uPAR Protein, Human (HEK293, His) Urokinase Plasminogen Activator surface receptor; U-PAR; CD87; PLAUR; MO3	Human	HEK293
	The uPAR protein is a receptor for urokinase plasminogen activator and actively localizes and promotes plasmin formation. It mediates proteolysis-independent signaling activated by U-PA and undergoes negative feedback regulation. uPAR Protein, Human (HEK293, His) is the recombinant human-derived uPAR protein, expressed by HEK293 , with C-6*His labeled tag. The total length of uPAR Protein, Human (HEK293, His) is 281 a.a., with molecular weight of ~52 kDa.

HY-P77276

	uPAR Protein, Mouse (HEK293, His) Urokinase Plasminogen Activator surface receptor; U-PAR; CD87; PLAUR; MO3	Mouse	HEK293
	The uPAR protein acts as a receptor for urokinase plasminogen activator, facilitating plasmin formation and signal transduction activation. It interacts with SRPX2 and forms a monomer. uPAR also interacts with MRC2 and SORL1, reducing PLAUR internalization. Additionally, the PLAUR-PLAU-SERPINE1 complex interacts with SORL1. uPAR Protein, Mouse (HEK293, His) is the recombinant mouse-derived uPAR protein, expressed by HEK293, with C-His labeled tag. The total length of uPAR Protein, Mouse (HEK293, His) is 297 a.a., with molecular weight of 50-60 kDa.

HY-P77275

	uPAR Protein, Mouse (HEK293, His-Fc) Urokinase Plasminogen Activator surface receptor; U-PAR; CD87; PLAUR; MO3	Mouse	HEK293
	uPAR (urokinase plasminogen activator receptor) possesses enzyme, protein, and receptor binding activities. It regulates apoptotic signaling, epidermal growth factor signaling, and cytochrome c release. uPAR is widely expressed in structures like decidua and spleen. Its human ortholog, PLAUR, is linked to rheumatoid arthritis. Investigating uPAR can reveal its role in cellular processes and shed light on diseases like rheumatoid arthritis. uPAR Protein, Mouse (HEK293, His-Fc) is the recombinant mouse-derived uPAR protein, expressed by HEK293 , with C-hFc, C-His labeled tag. The total length of uPAR Protein, Mouse (HEK293, His-Fc) is 274 a.a., with molecular weight of 80-90 kDa.

HY-P700875

	MRC2 Protein, Human (HEK293, His) C-type lectin domain family 13 member E, Endocytic receptor 180, Macrophage mannose receptor 2, Urokinase-type Plasminogen Activator receptor-associated protein (UPAR-associated protein; Urokinase receptor-associated protein)	Human	HEK293
	MRC2 Protein potentially acts as an endocytotic lectin receptor with calcium-dependent lectin activity. It internalizes glycosylated ligands through clathrin-mediated endocytosis, releasing them in endosomes. MRC2 may control PLAUR/PLAU levels in the plasminogen activation system, regulating cell surface protease activity. It contributes to cellular uptake, remodeling, and degradation of extracellular collagen matrices, influencing collagen turnover in cancer and tissue destructive diseases. MRC2 collaborates with matrix metalloproteinases, interacting with type I collagen, forming a tri-molecular complex with PLAUR/UPAR and PLAU/pro-UPA, and directly engaging with collagen V, highlighting its versatile role in cellular processes related to extracellular matrix dynamics. MRC2 Protein, Human (HEK293, His) is the recombinant human-derived MRC2 protein, expressed by HEK293, with C-His labeled tag. The total length of MRC2 Protein, Human (HEK293, His) is 500 a.a., with molecular weight of 65-75 kDa.

HY-P701528

	HLTF Protein, Human HLTF; Helicase-like transcription factor; DNA-binding protein/Plasminogen Activator inhibitor 1 regulator; HIP116; RING finger protein 80; RING-type E3 ubiquitin transferase HLTF; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3; Sucrose nonfermenting protein 2-like 3	Human	E. coli
	HLTF protein has helicase and E3 ubiquitin ligase activities and has intrinsic ATP-dependent nucleosome remodeling ability. It is critical for the transcriptional regulation of specific promoters such as SERPINE1, HIV-1 and SV40. HLTF Protein, Human is the recombinant human-derived HLTF protein, expressed by E. coli , with tag free. The total length of HLTF Protein, Human is 117 a.a., .

HY-P701529

	HLTF Protein, Human (His) HLTF; Helicase-like transcription factor; DNA-binding protein/Plasminogen Activator inhibitor 1 regulator; HIP116; RING finger protein 80; RING-type E3 ubiquitin transferase HLTF; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3; Sucrose nonfermenting protein 2-like 3	Human	E. coli
	HLTF protein has helicase and E3 ubiquitin ligase activities and has intrinsic ATP-dependent nucleosome remodeling ability. It is critical for the transcriptional regulation of specific promoters such as SERPINE1, HIV-1 and SV40. HLTF Protein, Human (His) is the recombinant human-derived HLTF protein, expressed by E. coli , with N-6*His labeled tag. The total length of HLTF Protein, Human (His) is 117 a.a., .

Cat. No.	Product Name	Chemical Structure

HY-B0099S

Edaravone-d5
Edaravone-d₅ is a deuterium labeled Edaravone. Edaravone is a strong novel free radical scavenger, and inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator[1][2][3][4].

HY-B0285AS

Amiloride-15N3 hydrochloride
Amiloride- ¹⁵N₃ (hydrochloride) is the ¹⁵N labeled Amiloride hydrochloride[1]. Amiloride hydrochloride (MK-870 hydrochloride) is an inhibitor of both epithelial sodium channel (ENaC[2]) and urokinase-type plasminogen activator receptor (uTPA[3]). Amiloride hydrochloride is a blocker of polycystin-2 (PC2;TRPP2[4]) channel.

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